Explore the latest peer-reviewed research with AI-generated summaries, key findings, and insights for easy understanding. All content is legally sourced from academic metadata with links to original papers.
BACKGROUND: Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains...
The M1/M2 macrophage paradigm plays a key role in tumor progression. Investigating TME-induced macrophage polarization is critical for further understanding of TAM-related pro-tumor outcomes and poten...
This research explores Efficacy and safety of a novel dual GIP and GLP-1 receptor a..., contributing new insights to the field of Medicine & Biology.
METHODS: After conducting preclinical in vitro and in vivo studies, we evaluated the safety and pharmacodynamic effects of single escalating doses of NTLA-2001 in six patients with hereditary ATTR amy...
BACKGROUND: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that is under development for the treatment of type 2 diabetes. CONC...
This research explores Ciltacabtagene autoleucel, a B-cell maturation antigen-direc..., contributing new insights to the field of Medicine & Biology.
Chronic kidney disease is a progressive disease with no cure and high morbidity and mortality that occurs commonly in the general adult population, especially in people with diabetes and hypertension....
This research explores Clinical validation of a targeted methylation-based multi-ca..., contributing new insights to the field of Medicine & Biology.
BACKGROUND: Lu)-PSMA-617 is a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment. CONCLUSIONS: Lu-PSMA-617 prolonged imaging-based...
The mechanisms of acquired resistance to these therapies are currently unknown. CONCLUSIONS: inhibitors, and new therapeutic strategies are required to delay and overcome this drug resistance in patie...
This research explores EASL Clinical Practice Guidelines on non-invasive tests for..., contributing new insights to the field of Medicine & Biology.
Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Here, we unite a...
Obstructive sleep apnea (OSA) is characterized by recurrent complete and partial upper airway obstructive events, resulting in intermittent hypoxemia, autonomic fluctuation, and sleep fragmentation. C...
This research explores Noncoding RNA therapeutics — challenges and potential soluti..., contributing new insights to the field of Medicine & Biology.
This research explores Fundamentals, status and promise of sodium-based batteries, contributing new insights to the field of Medicine & Biology.
We present a global analysis of the spread of recently emerged SARS-CoV-2 variants and estimate changes in effective reproduction numbers at country-specific level using sequence data from GISAID.
BACKGROUND: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. CONCLUSIONS: In patients with coma after out-of-hospital...
This research explores Sintilimab plus a bevacizumab biosimilar (IBI305) versus sor..., contributing new insights to the field of Medicine & Biology.
SoilGrids produces maps of soil properties for the entire globe at medium spatial resolution (250 m cell size) using advanced machine learning methods to generate the necessary models. The qualitative...
Inflammation is a key process in antimicrobial defence and tissue repair, and failure to properly regulate inflammation can result in tissue damage and death. Neural circuits play important roles thro...