Trial of Endovascular Thrombectomy for Large Ischemic Strokes

🤖 Plain-English Summary

BACKGROUND: Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations. Cerebral hemorrhages were infrequent in both groups.

🔑 Key Findings

• METHODS: We performed a prospective, randomized, open-label, adaptive, international trial involving patients with stroke due to occlusion of the internal carotid artery or the first segment of the middle cerebral artery to assess endovascular thrombectomy within 24 hours after onset.
• Patients had a large ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score of 3 to 5 (range, 0 to 10, with lower scores indicating larger infarction) or a core volume of at least 50 ml on computed tomography perfusion or diffusion-weighted magnetic resonance imaging.
• Patients were assigned in a 1:1 ratio to endovascular thrombectomy plus medical care or to medical care alone.

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