Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

🤖 Plain-English Summary

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs.

🔑 Key Findings

• These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs.
• Important advances have been made in EV metrology and in understanding and applying EV biology.
• However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies.

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