A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

🤖 Plain-English Summary

Neurodegenerative disorders are primarily characterized by neuron loss. This review briefly describes the pathophysiology of Alzheimer's, Parkinson's disease, and amyotrophic lateral sclerosis, and their current management approaches.

🔑 Key Findings

• The most common neurodegenerative disorders include Alzheimer's and Parkinson's disease.
• Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms.
• This lack of pathogenesis-targeting therapies is primarily due to the restrictive effects of the blood-brain barrier (BBB), which keeps close to 99% of all "foreign substances" out of the brain.

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