Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

🤖 Plain-English Summary

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

🔑 Key Findings

• The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases.
• Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.
• In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

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