Urinary biomarkers of kidney transplant rejection.

🤖 Plain-English Summary

Despite the introduction of many new immunosuppressive medications, allograft rejection remains a significant complication in transplantation. A contributing factor could be poor study design or quality of biospecimen repositories.

🔑 Key Findings

• The use of "liquid biopsy" to evaluate allograft function and detect early rejection has recently become a prominent focus of investigation as it holds promise in providing noninvasive and immediate insights into the cellular and molecular makeup of the graft.
• In recent years, the introduction of molecular medicine along with the use of new technologies, including high-throughput techniques, has not only accelerated biomarker discovery but has also contributed to improving our understanding of the mechanisms underlying immune rejection.
• Genomics, transcriptomics, and metabolomics approaches, along with the increasing use of machine learning techniques, have paved the way for the discovery and development of novel biomarkers.

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