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Trastuzumab Deruxtecan in HER2 -Mutant Non–Small-Cell Lung Cancer

📅 September 18, 2021 👤 Bob T. Li, Egbert F. Smit, Yasushi Goto et al. 📖 New England Journal of Medicine 📊 968 citations

🤖 Plain-English Summary

BACKGROUND: -mutant NSCLC have not been investigated extensively. Observed toxic effects were generally consistent with those in previously reported studies.

🔑 Key Findings

  • METHODS: -mutant NSCLC that was refractory to standard treatment.
  • The primary outcome was objective response as assessed by independent central review.
  • Secondary outcomes included the duration of response, progression-free survival, overall survival, and safety.

💡 Why This Matters

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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📋 Article Details

Category 🧬 Medicine & Biology
Published Sep 18, 2021
Journal New England Journal of Medicine
Authors Bob T. Li, Egbert F. Smit, Yasushi Goto, Kazuhiko Nakagawa, Hibiki Udagawa
DOI 10.1056/nejmoa2112431
Citations 968
Source OpenAlex

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