Translational models of addiction phenotypes to advance addiction pharmacotherapy.

🤖 Plain-English Summary

Alcohol and substance use disorders are heterogeneous conditions with limited effective treatment options. Opportunities for forward and reverse translation are also discussed.

🔑 Key Findings

• While there have been prior attempts to classify addiction subtypes, they have not been translated into clinical practice.
• In an effort to better understand heterogeneity in psychiatric disorders, the National Institute for Mental Health Research Domain Criteria (RDoC) has challenged scientists to think beyond diagnostic symptoms and to consider the underlying features of psychopathology from a neuroscience-based framework.
• The field of addiction has grappled with this approach by considering several key constructs with the potential to capture RDoC domains.

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