The neuroscience of cancer.

🤖 Plain-English Summary

The nervous system regulates tissue stem and precursor populations throughout life. Such cross-talk among the nervous system, immune system and cancer-both systemically and in the local tumour microenvironment-regulates pro-tumour inflammation and anti-cancer immunity.

🔑 Key Findings

• Parallel to roles in development, the nervous system is emerging as a critical regulator of cancer, from oncogenesis to malignant growth and metastatic spread.
• Various preclinical models in a range of malignancies have demonstrated that nervous system activity can control cancer initiation and powerfully influence cancer progression and metastasis.
• Just as the nervous system can regulate cancer progression, cancer also remodels and hijacks nervous system structure and function.

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