The mechanism of HMGB1 secretion and release

🤖 Plain-English Summary

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release.

🔑 Key Findings

• In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes.
• In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein.
• After its active secretion or passive release, extracellular HMGB1 usually acts as a damage-associated molecular pattern (DAMP) molecule, regulating inflammation and immune responses through different receptors or direct uptake.

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