The JAK/STAT signaling pathway: from bench to clinic

🤖 Plain-English Summary

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway.

🔑 Key Findings

• As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.
• Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.
• In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway.

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