Targeting PI3K/Akt signal transduction for cancer therapy

🤖 Plain-English Summary

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors. In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies consisting of signaling inhibitors and conventional cancer therapies.

🔑 Key Findings

• Examining the upstream and downstream nodes of this pathway could allow full elucidation of its function.
• Based on accumulating evidence, strategies targeting major components of the pathway might provide new insights for cancer drug discovery.
• Researchers have explored the use of some inhibitors targeting this pathway to block survival pathways.

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