SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples

🤖 Plain-English Summary

SynergyFinder (https://synergyfinder.fimm.fi) is a free web-application for interactive analysis and visualization of multi-drug combination response data. Based on user requests, several additional improvements were also implemented, including new data visualizations and export options for multi-drug combinations.

🔑 Key Findings

• Since its first release in 2017, SynergyFinder has become a popular tool for multi-dose combination data analytics, partly because the development of its functionality and graphical interface has been driven by a diverse user community, including both chemical biologists and computational scientists.
• Here, we describe the latest upgrade of this community-effort, SynergyFinder release 3.0, introducing a number of novel features that support interactive multi-sample analysis of combination synergy, a novel consensus synergy score that combines multiple synergy scoring models, and an improved outlier detection functionality that eliminates false positive results, along with many other post-analysis options such as weighting of synergy by drug concentrations and distinguishing between different modes of synergy (potency and efficacy).
• Based on user requests, several additional improvements were also implemented, including new data visualizations and export options for multi-drug combinations.

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