Obesity: Epidemiology, Pathophysiology, and Therapeutics

🤖 Plain-English Summary

Obesity is a complex multifactorial disease that accumulated excess body fat leads to negative effects on health. This review summarizes the global trends in obesity with a special focus on the pathogenesis of obesity from genetic factors to epigenetic factors, from social environmental factors to microenvironment factors.

🔑 Key Findings

• Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon.
• Raised body mass index (BMI) is a risk factor for noncommunicable diseases such as diabetes, cardiovascular diseases, and musculoskeletal disorders, resulting in dramatic decrease of life quality and expectancy.
• The main cause of obesity is long-term energy imbalance between consumed calories and expended calories.

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