Novel approaches to clinical trial design in cancer neuroscience.

🤖 Plain-English Summary

The emerging field of cancer neuroscience has revealed profound bidirectional interactions between the nervous system and cancer cells, identifying novel therapeutic vulnerabilities across diverse malignancies. Master protocols and window-of-opportunity trials provide platforms to rapidly validate mechanisms while addressing patient-centered outcomes.

🔑 Key Findings

• This review examines the unique challenges and strategies for translating these insights into effective therapies.
• We propose innovative approaches to overcome these barriers through drug repurposing, enhanced biomarker development, and optimized trial designs.
• Repurposing neuroactive drugs with established safety profiles offers an accelerated path to clinical impact, particularly for targeting glutamatergic, adrenergic, and neurotrophic signaling pathways.

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