New insights into the genetic etiology of Alzheimer’s disease and related dementias

🤖 Plain-English Summary

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia.

🔑 Key Findings

• We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls.
• We found 75 risk loci, of which 42 were new at the time of analysis.
• Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication.

🔗 Related Resources