Mitochondrial dysfunction: mechanisms and advances in therapy

🤖 Plain-English Summary

Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. We also summarize current strategies to treat mitochondrial dysfunction from the perspective of dietary supplements and targeted therapies, as well as the clinical translational situation of related pharmacology agents.

🔑 Key Findings

• Particularly, mitochondrial dysfunctions are identified in many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, and cancer.
• However, the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to diseases.
• Nonetheless, these complexities do not prevent mitochondria from being among the most important therapeutic targets.

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