Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

🤖 Plain-English Summary

Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension. We also discuss the current and latest knowledge about the histopathology and pathophysiology of the disease.

🔑 Key Findings

• The pathogenesis of MetS encompasses multiple genetic and acquired entities that fall under the umbrella of insulin resistance and chronic low-grade inflammation.
• If left untreated, MetS is significantly associated with an increased risk of developing diabetes and cardiovascular diseases (CVDs).
• Given that CVDs constitute by far the leading cause of morbidity and mortality worldwide, it has become essential to investigate the role played by MetS in this context to reduce the heavy burden of the disease.

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