Mapping the human genetic architecture of COVID-19

🤖 Plain-English Summary

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks.

🔑 Key Findings

• Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important.
• Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes.
• We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity.

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