KRAS mutation: from undruggable to druggable in cancer

🤖 Plain-English Summary

Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. This review summarises the most recent understanding of fundamental aspects of KRAS, the relationship between the KRAS mutations and tumour immune evasion, and new progress in targeting KRAS, particularly KRAS (G12C).

🔑 Key Findings

• As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention.
• The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases.
• However, KRAS has been deemed a challenging therapeutic target, even "undruggable", after drug-targeting efforts over the past four decades.

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