International Journal of Molecular Sciences

🤖 Plain-English Summary

Excess energy intake can trigger an uncontrolled inflammatory response, leading to systemic low-grade inflammation and metabolic disturbances that are hypothesised to contribute to cardiovascular disease and type 2 diabetes. Thetranscriptomicanalysisshowedchangesinβ-oxidationpathways, supporting the decreased lipid accumulation in the HFD-ED fed mice.

🔑 Key Findings

• The long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are suggested to mitigate this inflammatoryresponse,butthemechanismsareunclear,especiallyatthetissuelevel.
• Adiposetissues, the first tissues to give an inflammatory response, may be an important target site of action for EPA and DHA.
• To evaluate the effects of EPA and DHA in white and brown adipose tissues, we fed male C57Bl/6J mice either a high fat diet (HFD) with 5% corn oil, an HFD with 40% of the corn oil substituted for purified EPA and DHA triglycerides (HFD-ED), or normal chow, for 8 weeks.

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