International Journal of Molecular Medicine

🤖 Plain-English Summary

Growth factors and/or angiogenic factors are supposed to improve wound healing. These results suggest a beneficial effect of pretreatment with combinatory growth factors in mouse skin wounds without impaired wound healing.

🔑 Key Findings

• The aim of our study was to evaluate the effects of subcutaneous pretreatment with combinatory proangiogenic factors on wound closure, mechan-ical properties, vessel density and morphology.
• Twenty-eight Balb/c mice were divided equally into two groups.
• A mixture of VEGF (35.0 µg), bFGF (2.5 µg) and PdGF (3.5 µg) was administered subcutaneously 3, 5 and 7 days to 14 mice before full thickness skin punch biopsy wounding, whereas 14 control animals received three injections of 0.2 ml saline solution.

🔗 Related Resources