Inflammation and aging: signaling pathways and intervention therapies

🤖 Plain-English Summary

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Here we discuss inflammaging at the molecular, cellular, organ, and disease levels, and review current aging models, the implications of cutting-edge single cell technologies, as well as anti-aging strategies.

🔑 Key Findings

• Given the multidimensional complexity of aging, there is an urgent need for a systematic organization of inflammaging through dimensionality reduction.
• Factors secreted by senescent cells, known as the senescence-associated secretory phenotype (SASP), promote chronic inflammation and can induce senescence in normal cells.
• At the same time, chronic inflammation accelerates the senescence of immune cells, resulting in weakened immune function and an inability to clear senescent cells and inflammatory factors, which creates a vicious cycle of inflammation and senescence.

🔗 Related Resources