Improved prediction of protein-protein interactions using AlphaFold2

🤖 Plain-English Summary

Predicting the structure of interacting protein chains is a fundamental step towards understanding protein function. From the predicted interfaces we create a simple function to predict the DockQ score which distinguishes acceptable from incorrect models as well as interacting from non-interacting proteins with state-of-art accuracy.

🔑 Key Findings

• Unfortunately, no computational method can produce accurate structures of protein complexes.
• AlphaFold2, has shown unprecedented levels of accuracy in modelling single chain protein structures.
• Here, we apply AlphaFold2 for the prediction of heterodimeric protein complexes.

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