Gut microbiome and health: mechanistic insights

🤖 Plain-English Summary

The gut microbiota is now considered as one of the key elements contributing to the regulation of host health. Numerous molecular mechanisms explaining how gut bacteria might be causally linked with the protection or the onset of diseases are discussed.

🔑 Key Findings

• Virtually all our body sites are colonised by microbes suggesting different types of crosstalk with our organs.
• Because of the development of molecular tools and techniques (ie, metagenomic, metabolomic, lipidomic, metatranscriptomic), the complex interactions occurring between the host and the different microorganisms are progressively being deciphered.
• Nowadays, gut microbiota deviations are linked with many diseases including obesity, type 2 diabetes, hepatic steatosis, intestinal bowel diseases (IBDs) and several types of cancer.

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