Guidelines for performing Mendelian randomization investigations: update for summer 2023

🤖 Plain-English Summary

<ns3:p>This paper provides guidelines for performing Mendelian randomization investigations. These guidelines will be updated based on feedback from the community and advances in the field.

🔑 Key Findings

• It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts.
• The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation.
• These guidelines will be updated based on feedback from the community and advances in the field.

🔗 Related Resources