Functional Genomics in Psoriasis.

🤖 Plain-English Summary

Psoriasis is an autoimmune cutaneous condition that significantly impacts quality of life and represents a burden on society due to its prevalence. In this review, we aim to elucidate the main findings in this field and integrate our discussion with gold-standard techniques in molecular biology-i.e., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-and high-throughput technologies.

🔑 Key Findings

• Genome-wide association studies (GWASs) have pinpointed several psoriasis-related risk loci, underlining the disease's complexity.
• Functional genomics is paramount to unveiling the role of such loci in psoriasis and disentangling its complex nature.
• In this review, we aim to elucidate the main findings in this field and integrate our discussion with gold-standard techniques in molecular biology-i.e., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-and high-throughput technologies.

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