Functional Drug Screening in the Era of Precision Medicine.

🤖 Plain-English Summary

The focus of precision medicine is providing the right treatment to each unique patient. In this review, we discuss the practicality of various 3D drug screening models and each model's ability to capture the patient's tumor microenvironment.

🔑 Key Findings

• This scientific movement has incited monumental advances in oncology including the approval of effective, targeted agnostic therapies.
• Yet, precision oncology has focused largely on genomics in the treatment decision making process, and several recent clinical trials demonstrate that genomics is not the only variable to be considered.
• Drug screening in three dimensional (3D) models, including patient derived organoids, organs on a chip, xenografts, and 3D-bioprinted models provide a functional medicine perspective and necessary complement to genomic testing.

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