Extracellular vesicles as tools and targets in therapy for diseases

🤖 Plain-English Summary

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future.

🔑 Key Findings

• They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions.
• Human serum is a rich source of these EVs, though their isolation from serum proteins and non-EV lipid particles poses challenges.
• These vesicles transport various cellular components such as proteins, mRNAs, miRNAs, DNA, and lipids across distances, influencing numerous physiological and pathological events, including those within the tumor microenvironment (TME).

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