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Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes

📅 May 24, 2024 👤 Vlado Perkovic, Katherine R. Tuttle, Peter Rossing et al. 📖 New England Journal of Medicine 📊 1,472 citations

🤖 Plain-English Summary

BACKGROUND: Patients with type 2 diabetes and chronic kidney disease are at high risk for kidney failure, cardiovascular events, and death. CONCLUSIONS: Semaglutide reduced the risk of clinically important kidney outcomes and death from cardiovascular causes in patients with type 2 diabetes and chronic kidney disease.

🔑 Key Findings

  • Whether treatment with semaglutide would mitigate these risks is unknown.
  • METHODS: ), at least a 50% reduction in the eGFR from baseline, or death from kidney-related or cardiovascular causes.
  • Prespecified confirmatory secondary outcomes were tested hierarchically.

💡 Why This Matters

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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📋 Article Details

Category 🧬 Medicine & Biology
Published May 24, 2024
Journal New England Journal of Medicine
Authors Vlado Perkovic, Katherine R. Tuttle, Peter Rossing, Kenneth W. Mahaffey, Johannes F.E. Mann
DOI 10.1056/nejmoa2403347
Citations 1,472
Source OpenAlex

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