Ulcerative colitis [UC] is a chronic inflammatory bowel disease [IBD] characterised by colonic inflammation extending to a variable extent from the rectum. These definitions of disease extent are recognised as somewhat arbitrary; in clinical practice, topically administered therapies are often used for UC whose extent is limited to the rectum and a portion of the sigmoid colon [proctosigmoiditis], with the term ‘distal colitis’ used to describe this disease distribution.
Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.
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| Category | 🧬 Medicine & Biology |
| Published | Oct 08, 2021 |
| Journal | Journal of Crohn s and Colitis |
| Authors | Tim Raine, Stefanos Bonovas, Johan Burisch, Torsten Kucharzik, Michel Adamina |
| DOI | 10.1093/ecco-jcc/jjab178 |
| Citations | 1,010 |
| Source | OpenAlex |