Diagnosing chronic endometritis: when simplification fails to clarify.

🤖 Plain-English Summary

Reproductive immunology has grown in importance in recent years and has even developed into a discipline of its own within the field of reproductive medicine. the immunologic rejection and tolerance of an embryo.

🔑 Key Findings

• Many aspects of reproductive failure such as repeated implantation failure or recurrent miscarriages are, meanwhile, seen as a consequence of aberrant expression of immunological factors.
• This is reflected by the increasing number of tests for assessing and quantifying different immune cell types as well as by a wide range of immune therapies offered to a clientele consisting of desperate patients requesting additional 'IVF tools': first, what is still usually disregarded is the enormous plasticity and fluctuation of most immune cells in the genital tract; second, their still poorly characterized functions in the endometrial cycle: further, their partially unknown role in embryo implantation and in establishing a pregnancy; and third, the fact that one of the fundamental hypotheses of reproductive immunology-of note-the Medawar concept or 'Medawar's Paradox' of semi-allogeneic graft embryo, is partially based on an erroneous assumption, i.e.
• the immunologic rejection and tolerance of an embryo.

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