Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks.

🤖 Plain-English Summary

Neural reflexes occupy a central role in physiological homeostasis. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy.

🔑 Key Findings

• The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain.
• Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions.
• Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy.

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