Challenges in the application of NGS in the clinical laboratory.

🤖 Plain-English Summary

Next-generation sequencing (NGS), also known as massively parallel sequencing, has revolutionized genomic research. Challenges of NGS implementation in the clinical laboratory are also discussed, including sequencing error rate, bioinformatics, result interpretation, analytic sensitivity, as well as large data storage.

🔑 Key Findings

• The current advances in NGS technology make it possible to provide high resolution, high throughput HLA typing in clinical laboratories.
• The focus of this review is on the recent development and implementation of NGS in clinical laboratories.
• Here, we examine the critical role of NGS technologies in clinical immunology for HLA genotyping.

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