Bacterial Antibiotic Resistance: The Most Critical Pathogens

🤖 Plain-English Summary

Antibiotics have made it possible to treat bacterial infections such as meningitis and bacteraemia that, prior to their introduction, were untreatable and consequently fatal. In this review, both the mode of action and the mechanisms of resistance of commonly used antimicrobials will be examined.

🔑 Key Findings

• Unfortunately, in recent decades overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making drug treatment ineffective.
• Currently, at least 700,000 people worldwide die each year due to antimicrobial resistance (AMR).
• Without new and better treatments, the World Health Organization (WHO) predicts that this number could rise to 10 million by 2050, highlighting a health concern not of secondary importance.

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