Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development.

🤖 Plain-English Summary

Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10-100 nucleotides in length. Here, we critically review neuro-targeting aptamers and their potential applications in neuroscience research, neuro-diagnostics, and neuro-medicine.

🔑 Key Findings

• Their targets, often with specificity and high affinity, range from ions and small molecules to proteins and other biological molecules as well as larger systems, including cells, tissues, and animals.
• Aptamers often rival conventional antibodies with improved performance, due to aptamers' unique biophysical and biochemical properties, including small size, synthetic accessibility, facile modification, low production cost, and low immunogenicity.
• Therefore, there is sustained interest in engineering and adapting aptamers for many applications, including diagnostics and therapeutics.

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