A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

🤖 Plain-English Summary

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.

🔑 Key Findings

• Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified.
• Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease.
• This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.

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