The mechanism of HMGB1 secretion and release

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes.
• 2 In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein.
• 3 After its active secretion or passive release, extracellular HMGB1 usually acts as a damage-associated molecular pattern (DAMP) molecule, regulating inflammation and immune responses through different receptors or direct uptake.

This work deepens our understanding of the fundamental laws governing the universe, from subatomic particles to cosmic structures.

This summary is based on publicly available metadata and abstract. For the full research paper, visit the original source: