Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock

BACKGROUND: The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock remains unclear. The incidence of a composite of adverse events was higher with the use of the microaxial flow pump.

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• 1 METHODS: In an international, multicenter, randomized trial, we assigned patients with STEMI and cardiogenic shock to receive a microaxial flow pump (Impella CP) plus standard care or standard care alone.
• 2 The primary end point was death from any cause at 180 days.
• 3 A composite safety end point was severe bleeding, limb ischemia, hemolysis, device failure, or worsening aortic regurgitation.

This work deepens our understanding of the fundamental laws governing the universe, from subatomic particles to cosmic structures.

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