Implications of Adnexal Invasions in Primary Extramammary Paget’s Disease: A Systematic Review

Extramammary Paget’s disease (EMPD) is an erratic malignant skin disorder primarily affecting skin areas abundant with skin appendages like hair follicles. Surgical excision, including Mohs micrographic surgery, is the primary therapeutic approach, with topical agents and systemic treatments used in advanced cases.

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• 1 The vulva is most involved site, followed by genital areas, penoscrotal regions and axillary skin.
• 2 EMPD presents as erythematous skin lesions resembling eczema, typically progressing slowly, either primary or secondary manifestations.
• 3 Primary EMPD originates as an intraepithelial neoplasm of the epidermis, often leading to local lymph node metastases and distant metastases.

This work deepens our understanding of the fundamental laws governing the universe, from subatomic particles to cosmic structures.

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