Guidelines for performing Mendelian randomization investigations: update for summer 2023

<ns3:p>This paper provides guidelines for performing Mendelian randomization investigations. These guidelines will be updated based on feedback from the community and advances in the field.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts.
• 2 The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation.
• 3 These guidelines will be updated based on feedback from the community and advances in the field.

This work deepens our understanding of the fundamental laws governing the universe, from subatomic particles to cosmic structures.

This summary is based on publicly available metadata and abstract. For the full research paper, visit the original source: