Ferroptosis in cancer and cancer immunotherapy

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized.

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• 1 Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry.
• 2 The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure.
• 3 The effective rate of tumor immunotherapy as a new treatment method is less than 30%.

This work deepens our understanding of the fundamental laws governing the universe, from subatomic particles to cosmic structures.

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