Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases.
• 2 Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.
• 3 In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

This summary is based on publicly available metadata and abstract. For the full research paper, visit the original source: