Understanding the evolution of immune genes in jawed vertebrates.

Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species.
• 2 However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into-and generate evolutionary hypotheses on-the ultimate drivers of immunological differences.
• 3 Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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