The JAK/STAT signaling pathway: from bench to clinic

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.
• 2 Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.
• 3 In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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