SignalP 6.0 predicts all five types of signal peptides using protein language models

Signal peptides (SPs) are short amino acid sequences that control protein secretion and translocation in all living organisms. SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs.

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• 1 SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs.
• 2 We introduce SignalP 6.0, a machine learning model that detects all five SP types and is applicable to metagenomic data.

This research advances how AI systems learn, reason, and solve problems — with direct implications for automation and scientific discovery.

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