New strategies to improve minimap2 alignment accuracy

SUMMARY: We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness in minimap2 v2.18 or earlier.

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• 1 Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness in minimap2 v2.18 or earlier.
• 2 AVAILABILITY AND IMPLEMENTATION: https://github.com/lh3/minimap2.

This research advances how AI systems learn, reason, and solve problems — with direct implications for automation and scientific discovery.

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