New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia.

⚡ This is an original paraphrased summary — not copied from the abstract. Full paper available at the source link below.

• 1 We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls.
• 2 We found 75 risk loci, of which 42 were new at the time of analysis.
• 3 Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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