Multiple early factors anticipate post-acute COVID-19 sequelae

T cells exhibited unique dynamics during recovery from COVID-19. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states.

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• 1 Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC.
• 2 We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states.
• 3 Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies.

Understanding this could lead to better treatments, improved diagnostics, or a deeper grasp of how the human body works — benefiting patient care globally.

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