Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence

BACKGROUND: Single group data present unique challenges for synthesises of evidence. We provide worked examples of how proportional meta-analyses have been conducted in research syntheses previously and consider the methods, statistical considerations, and presentation of this technique.

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• 1 Proportional meta-analysis is becoming an increasingly common technique employed for the synthesis of single group data.
• 2 Proportional meta-analysis shares many similarities with the conduct and reporting of comparative, or pairwise, meta-analysis.
• 3 While robust and comprehensive methods exist detailing how researchers can conduct a meta-analysis that compares two (or more) groups against a common intervention, there is a scarcity of methodological guidance available to assist synthesisers of evidence in the conduct, interpretation, and importance of proportional meta-analysis in systematic reviews.

This research advances how AI systems learn, reason, and solve problems — with direct implications for automation and scientific discovery.

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